Faculty and Staff News
IUSM to take part in national pancreatitis research consortium
The Indiana University School of Medicine is one of 10 members selected to take part in a national Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer, with $1.86 million in funding over five years.
This CSCPDPC award, a U01 research project, is funded by the National Institutes of Health, the National Cancer Institute and the National Institute of Diabetes and Digestive and Kidney Diseases.
The two objectives of the research consortium are to pursue clinical research on chronic pancreatitis and acute recurrent pancreatitis, and on pancreatic cancer and pancreatogenic diabetes mellitus. Through recruitment and acquisition of well-characterized patients and associated biospecimens, this research network will achieve the research objectives.
Evan Fogel, M.D., professor of clinical medicine is the principal investigator on this award. Other investigators include Stuart Sherman, M.D., Murray Korc, M.D., Kieren Mather, M.D., Raghu Mirmira, M.D., Ph.D., Temel Tirkes, M.D., and Kumar Sandrasegaran, M.D.
The consortium also includes the University of Iowa, Cedars Sinai LA, the Mayo Clinic, Stanford University, Baylor University, Indiana University, the University of Florida, the Kaiser Foundation and the University of Pittsburgh. The University of Texas MD Anderson Cancer Center is the consortium’s Data Coordination and Management Center.
IUSM expands partnership with MedHub to support reaccreditation efforts
The IU School of Medicine has expanded its partnership with MedHub to deploy medical education management software that will enhance service to learners.
Considered a best-in-class tool for managing student data, processing, billing and other functions, MedHub has already been an important partner for Graduate Medical Education for many years. Now, given the important needs associated with IUSM’s pursuit of reaccreditation and related curriculum renewal, MedHub will be deployed across the school beginning this fall.
MedHub will help better serve learners by making it easier for faculty to enter grades, by creating smooth workflows, and by preventing missing, duplicated or conflicting data.
“Campuses and programs will have the ability to talk to one another through this system, creating efficiencies that mean less administrative effort and higher-quality data that support work toward reaccreditation and ultimate goals of continuous quality improvement in all aspects of our work,” said Peter Nalin, executive associate dean for educational affairs.
A few examples of work that MedHub will support:
Curricular mapping (current legacy curriculum and the new curriculum)
Course scheduling, conference attendance, distribution of curricula, and evaluations
Extensive reporting capabilities across the enterprise, statewide and inter-professional.
Kurt Snyder, director of the division of continuing medical education, is leading MedHub deployment.
School-wide Grand Rounds presentation now available online
On Sept. 30, IUSM hosted its school-wide Grand Rounds, “Industry Relations Conflict of Interest -- A Panel Discussion.”For those who were unable to attend in person, the presentation is now available online.
IUSM receives more than $16 million in new grants and awards in September
Sunil Badve National Cancer Institute New (PQC3) Ethnicity-determined immune response and DCIS outcome 8/4/15 7/31/16 707,173 Nerissa S Bauer Agency For Healthcare Research And Quality New Improving Anxiety Detection in Pediatrics Using Health Information Technology 9/1/15 8/31/17 298,960 Aaron E Carroll National Institute Of General Medical Sciences New Utilizing Established YouTube Infrastructure for Training Module Development 9/15/15 8/31/16 71,696 Rebecca J Chan National Cancer Institute Renewal (not prev committed) International Symposium on Juvenile Myelomonocytic Leukemia (JMML) 9/1/15 8/31/16 4,000 D Wade Clapp Riley Children's Foundation New Hematology/Oncology Section Chief Recruitment 7/1/15 6/30/16 800,000 D Wade Clapp National Cancer Institute New Developmental and HyperActive Ras Tumor SPORE 9/1/15 8/31/16 199,507 D Wade Clapp National Cancer Institute New Developmental and HyperActive Ras Tumor SPORE 9/1/15 7/31/16 2,185,000 Theodore R Cummins National Institute Neurological Disorders & Stroke New Sodium channels and electrogenesis in sensory neurons 9/1/15 8/31/16 390,000 Jeffrey S Elmendorf Beckman Research Institute City Of Hope New Support to continue her AHA fellowship for this time 7/1/15 12/31/15 10,000 Tatiana M Foroud Michael J Fox Foundation For Parkinsons Research New Systemic Synuclein Sampling Study (S4) 5/1/15 4/30/16 386,050 Tatiana M Foroud National Institute Neurological Disorders & Stroke New NINDS Biomarker Repository 9/30/15 9/29/16 1,500,000 Maria Bartolomeo Grant National Eye Institute New LXR as a novel therapeutic target in diabetic retinopathy 9/1/15 8/31/16 582,429 Chandy C John Riley Children's Foundation New Ryan White Infectious Disease Research Fund 7/1/15 6/30/16 850,125 Chandy C John University Of Bergen New University of Bergen 10/1/14 9/30/19 9,433 Reuben Kapur Children's Hospital Medical Center Of Cincinnati New Regulation of hematopoietic stem cell self-renewal by GTPase activating protein sign 7/1/15 6/30/16 17,807 Sungeun Kim National Institute On Aging New Novel Strategies for Blood-based Biomarkers for AD: Role of Genetic Variation in a Multivariate Framework 9/1/15 4/30/16 78,000 Shyam Kishan Ann & Robert H Lurie Children Hospital Of Chi New Evaluating the Need for Operative Management of Type I Open Fractures in Children 9/4/15 11/30/15 600 Debomoy K. Lahiri National Institute On Aging New Neurobiological role of MicroRNA in Alzheimer's 9/1/15 4/30/16 319,743 Debra K Litzelman Indiana University Health New Institutionalizing Advance Care Planning in Key Communities Across Indiana 7/1/15 6/30/16 138,654 Patrick J. Loehrer National Cancer Institute Renewal (not prev committed) Indiana University Melvin and Bren Simon Cancer Center Summer Program 9/1/15 8/31/16 106,993 Daniela Elena Matei Purdue University New Diffractometric Detection of Molecular Cancer Markers 8/1/15 7/31/16 99,456 Erin M B McNerny National Institute Of Diabetes, Digestive & Kidney New Assessing and improving bone quality in chronic kidney disease 9/17/15 9/16/16 53,623 Raghu G Mirmira Riley Children's Foundation New Wm & Helen Thomas Trust 8/31/15 2/29/16 20,000 Anirban Kumar Mitra U.s. Department Of Defense New Microenvironment regulated microRNAs promote ovarian cancer metastatic colonization 9/1/15 8/31/20 1,131,000 Christie M Orschell U.s. Department Of Defense New Using the prostaglandin E2 signaling cascade to mitigate the effects of acute and delayed radiation exposure to hematopoiesis and blood stem cell function. 9/1/15 8/31/18 1,165,121 Christie M Orschell U.s. Department Of Defense New Development of G1T28-1 to Mitigate Hematologic Sequelae of ARS and DEARE 9/30/15 9/29/16 274,448 Louis M Pelus U.s. Department Of Defense New Using the prostaglandin E2 signaling cascade to mitigate the effects of acute and delayed radiation exposure to hematopoiesis and blood stem cell function 9/1/15 8/31/18 1,171,743 Susanne Ragg Riley Children's Foundation New Broadwater Funds for Osteosarcoma Research 8/1/14 12/31/15 15,000 Tony Ribera International Association Of Medical Science Educators New Examining the Response Process Validity of Learner Mistreatment Items on the Association of American Medical Colleges? Medical School Graduation Questionnaire 6/15/15 6/14/17 2,998 Zachary A. Rodd National Institute On Alcohol Abuse And Alcoholism New 7/8 NADIA UO1 Adolescent Alcohol and Neurocircuitry Mediating Ethanol Reinforcement 9/1/15 8/31/16 315,900 G David Roodman University Of Pittsburgh Renewal (not prev committed) Viral and Genetic Regulation of Abnormal OCL Activity in PD 8/1/15 6/30/16 28,704 Uma Sankar National Institute Arthritis Musculoskeletal Skin New CaMKK2 Inhibition as a Dual-Action Bone Anabolic and Anti-Catabolic Therapy in Osteoporosis 9/18/15 7/31/16 337,286 Uma Sankar American Cancer Society, Incorporated New CaMKK2 Inhibition in Palliative Care of Advanced Prostate Cancer Patients 7/1/15 6/30/16 180,000 Patrick L Sheets National Institute Neurological Disorders & Stroke New Prefrontal Circuitry and Pain 9/30/15 6/30/16 320,219 Edward F. Srour National Institute Of Diabetes, Digestive & Kidney New CD 166 Regulates Human and Murine Hematopoietic Stem Cell Function and the Hematopoietic Niche 9/11/15 8/31/16 124,800 Michael S Sturek Purdue University New In vivo photoacoustic sensing of lipid laden plaque 8/1/15 5/31/16 120,799 Jie Sun National Institute On Aging New Simultaneously boosting both humoral and cellular immunity following vaccination 9/1/15 5/31/16 319,800 Naomi B Swiezy Riley Children's Foundation New HANDS in Autism Interdisciplinary Training and Resource Center Fund #2377 FY-16 7/1/15 6/30/16 15,815 Yuichiro Takagi National Institute Of General Medical Sciences New Mechanism of transcription regulation by the Mediator 9/1/15 8/31/16 305,934 Robert S. Tepper National Heart, Lung And Blood Institute New Anti-Angiogenic Preeclamptic Milieu Impairs Infant Lung and Vascular Development 9/15/14 5/31/15 623,699 Homer L Twigg Johns Hopkins University New Measurement of HIV viral load and detection of viruses in the lungs of HIV-infected subjects on highly active antiretroviral therapy 8/1/15 7/31/16 55,683 Benjamin M Whittam National Institute Of Diabetes, Digestive & Kidney New Randomized Robotic-Assisted versus Open surgery: Benefits and Patient Centered Outcomes Trial(Randomized ROBOT) 9/3/15 8/31/16 234,000 Sarah Elizabeth Wiehe Indiana State Department Of Health New The Indiana Clinical and Translational Sciences Institute (CTSI) - Community Health Engagement Program (CHEP) Preventive Health and Health Services Block Grant 7/20/15 9/30/16 140,652 Bryan K Yamamoto National Institute On Drug Abuse New Methamphetamine Toxicity and Corticostriatal Glutamate 7/1/15 4/30/16 254,999 Mervin C. Yoder Riley Children's Foundation New Wells Center summer internship 5/1/15 4/30/16 16,500 Richard C Zellars The Breast Cancer Research Foundation New Phase II Trial of Partial Breast Cancer Irradiation and Concurrent Chemotheray (PBI 3.0) / Pre-operative PARPi and Irradiation (POPI) 10/1/16 9/30/17 70,470 Richard C Zellars The Breast Cancer Research Foundation New Phase II Trial of Partial Breast Cancer Irradiation and Concurrent Chemotheray (PBI 3.0) / Pre-operative PARPi and Irradiation (POPI) 10/1/15 9/30/16 179,530
Study: Gene linked to amyloid beta plaque buildup in Alzheimer's disease
In a newly published study, a multi-institutional team led by scientists at the Indiana University School of Medicine have discovered an immune system gene associated with higher rates of amyloid plaque buildup in the brains of Alzheimer’s patients and older adults at risk for the disease.
The research, reported in the journal Brain, found that a variant in the IL1RAP gene was associated with greater amyloid plaque accumulation over two years and had an even stronger effect than the well-known APOE e4 allele which is notorious for its association with the development of Alzheimer’s disease.
Using positron emission tomography imaging in nearly 500 individuals, the researchers assessed the levels of brain amyloid deposits at an initial visit and again two years later. A genome-wide analysis was then conducted to identify genetic variants associated with the rate of plaque accumulation during this two-year window. As predicted, APOE e4 was found to be associated with higher rates of plaque buildup. However, the investigators were surprised to find that IL1RAP, which codes for the key immune signaling factor Interleukin-1 Receptor Accessory Protein, showed an independent and even stronger influence on amyloid accumulation.
The new study in Brain found that the amyloid-associated IL1RAP variant was also associated with:
A lower level of microglial activity as measured by PET scans.
Greater atrophy of the temporal cortex, a region of the brain involved with memory.
Faster cognitive decline.
Greater likelihood among study participants of progression from mild cognitive impairment to Alzheimer's disease.
To read more about this study, visit the IUSM Newsroom.
Corson awarded $100,000 research grant to study pediatric eye cancer
Timothy Corson, Ph.D., assistant professor of ophthalmology at the IU School of Medicine and researcher at the Indiana University Melvin and Bren Simon Cancer Center and the Eugene and Marilyn Glick Eye Institute, has been awarded a $100,000 Research Grant Award from the St. Baldrick’s Foundation to support his research on retinoblastoma, a cancer of the eye in children that can cause blindness or death.
The award provides funding for year-long research projects that look to find new and better cures for childhood cancers, according to the foundation.
Dr. Corson’s team has developed a new chemical that blocks abnormal blood vessel growth in the eye without side effects. By blocking new blood vessel formation, they will starve a growing retinoblastoma tumor of oxygen and nutrients and stop its growth. If successful, this work will pave the way for development of a new retinoblastoma drug and also testing in other pediatric and adult cancers.
Faculty and Staff News
Mathur receives CHEST award, will give memorial lecture at annual meeting
The IU School of Medicine’s Praveen N. Mathur, MBBS, FCCP, professor emeritus of clinical medicine, will receive the Pasquale Ciaglia award and give the Pasquale Ciaglia memorial lecture in Interventional Medicine at the 2015 American College of Chest Physicians annual meeting.
The Pasquale Ciaglia Memorial Lecture in Interventional Medicine and award honors a CHEST member well-known for his or her work in interventional medicine, such as clinical state-of-the-art innovations, economic impact, invention, interventional critical care, research opportunities and/or a host of other interesting facets of interventional medicine.
CHEST 2015 takes place Oct. 24 - 28 in Montreal, Canada. Learn more about CHEST and its annual meeting.
Sevilla-Martîr elected president of Indiana Hispanic Medical Society
Javier Sevilla-Martîr, M.D., was elected the first president of the newly inaugurated Indiana Hispanic Medical Society on Sept. 26 at the regional meeting of the National Hispanic Medical Association.
Sevilla-Martîr is the associate professor of clinical family medicine and assistant dean of diversity affairs at the IU School of Medicine. The president and CEO of the National Hispanic Medical Association, Elena Rios, M.D., was on hand to preside over the regional meeting.
Serving with Dr. Sevilla as new officers of the Indiana Hispanic Medical Society, will be:
Alfredo Lopez, M.D., vice president
Daniela Lobo, M.D., secretary
Ruben Hernandez, M.D., treasurer
A first-year medical student, Gustavo Caravjal, was elected to the Board of Directors as the medical student representative. Please congratulate these leaders as they help shape healthcare in Indiana with a special focus on Hispanic/Latino community members.
Jones and Zellars named to endowed chairs
Kathryn J. Jones, Ph.D., has been recommended to become the first holder of the Vincent H. Gattone II Chair in Anatomy & Cell Biology with the title of Vincent H. Gattone II Professor of Anatomy & Cell Biology, pending the president’s approval. Dr. Jones is currently chair, Department of Anatomy & Cell Biology, and also holds the titles of joint professor of neurological surgery and professor of otolaryngology-head & neck surgery.
Richard C. Zellars, M.D., has been recommended to become the fourth holder of the William A. Mitchell Chair in Radiation Oncology with the title of William A. Mitchell Professor of Radiation Oncology, pending the President’s approval. Dr. Zellars is currently chair, Department of Radiation Oncology.
Chambers and Tate named OFAPD faculty fellows
Joanna Chambers, M.D., and Chemen Tate, M.D., have been named Faculty Fellows in the Office of Faculty Affairs and Professional Development with an emphasis on women’s initiatives and diversity.
Dr. Chambers, an assistant professor of clinical psychiatry, came to the IU School of Medicine in 2007 and has served in various educational roles, including associate residency training director, residency training director, and vice chair for education.
Since her arrival to Indiana University in 2008, Dr. Tate, an assistant professor in the Department of Obstetrics and Gynecology, has served as an attending physician at Community Hospital North, Eskenazi Health, and IU Health.
“We are particularly excited about their interest in examining the intersection of gender and diversity—with learners, staff and faculty. Their contributions to this important work will help us learn how to improve the climate, culture and experiences for everyone at IUSM but especially those from underrepresented groups,” said Mary Austrom, Ph.D., associate dean for diversity affairs.
The fellowship is designed to advance the collaboration between programs for the advancement of women and diversity affairs, while providing an opportunity to professional growth and development.
Zyromski featured on IU Health’s Blog
When he’s not performing surgery, Nicholas Zyromski is making music. A surgeon specializing in pancreatic and hepatobiliary (liver, gallbladder and bile duct) surgery at IU Health University Hospital and associate professor of surgery at the IU School of Medicine, Zyromski spends his weekends and free time playing, writing and performing his own music. Read the full Q&A with the musician/surgeon on the IU Health Blog.
Indiana Association of Blacks in Higher Education Fall 2015 Symposium is Oct. 14
The Indiana Association of Blacks in Higher Education Fall Symposium will take place Wednesday, Oct. 14 at the IUPUI Campus Center from 9 am to 2:30 pm.
The purpose of the IABHE is to promote the advancement of Indiana blacks in higher education. The IABHE serves to create a space for black administrators, faculty, staff, and graduate students to professionally network, engage in personal fellowship, and show support of each other while working at institutions within Indiana.
The one-day symposium will include a continental breakfast, an address from the Indiana Commission on HIgher Education titled, “The State of Black Students in Higher Education,” lunch with student hosts and affinity group breakout sessions.
Click here to register or to learn more about this event.
2015 Innovation to Enterprise Showcase and Forum Nov. 4
The Innovation to Enterprise Showcase and Forum, which highlights the research and creative successes of IU faculty, researchers and students will take place at the IUPUI Campus Center on Wednesday, Nov. 4.
This year’s keynote speaker is Richard DiMarchi, Ph.D., co-founder of five companies and former group vice president for Eli Lilly & Company. The event will also recognize faculty innovation and social impact with the presentation of the inaugural Innovation to Enterprise Research Commercialization Award.
The event will conclude with a networking reception and showcase featuring new ventures arising from faculty research at the Indianapolis campus, hosted by SpinUp Business Catalyst group. SpinUP was created to help IU researchers bring promising technologies to market by starting their own companies, and helps with the early administrative functions of running a business so faculty members can focus on the research that drives it.To register, click here. Contact Karen White at email@example.com or (317) 274-1083 with questions about this event.
HANDS in Autism® workshop for families, providers and individuals with ASD
HANDS in Autism® will host a Next Steps™ workshop in Fesler Hall, room 302, Wednesday, Oct. 28, from 5:30 to 7:30 pm.
The workshop will cover a variety of topics, including:
General information on autism spectrum disorder
Information on family life
Rights and regulations
Treatment and intervention