Faculty and Staff News
Researchers receive nearly $3 million for studies to help caregivers of patients with cognitive disorders
challenges for which they are often unprepared and unsupported. Health services researcher Nicole Fowler, PhD, MHSA, of Indiana University School of Medicine, the IU Center for Aging Research, Regenstrief Institute and IU Center for Health Innovation and Implementation Science, and colleagues have received grants from the National Institute on Aging (NIA) and the United States Department of Defense totaling nearly $3 million to fund two novel studies focusing on helping family caregivers of individuals with Alzheimer’s disease and related dementias or traumatic brain injury.
A $2.2 million, five-year NIA award funds the randomized control Decisions about Cancer Screening in Alzheimer's Disease study, known as DECAD, to investigate if an evidence-based mammography screening decision aid can improve the quality of medical decision making among caregivers by lowering their decisional conflict and increasing their confidence in making mammography decisions for older women with Alzheimer’s disease.
“Family caregivers are often the ones making tough decisions and facilitating medical care for their loved ones with Alzheimer’s disease," Dr. Fowler said. “They struggle with decisions about care, especially those that they are not sure will improve their loved ones’ quality of life and may be burdensome. For example, imagine you are a woman with Alzheimer's disease being taken out of your familiar surroundings to get a mammogram and you don't really know or understand what is going on, what is being done to your body; then imagine how difficult it can be for the caregiver to make the decision to take their confused family member to the imaging facility and keep them calm and comfortable."
National guidelines on mammography screening in older women vary and some address the need to tailor guidelines for women with serious, life-limiting illnesses such as Alzheimer’s disease. It is estimated that over 800,000 older women with Alzheimer’s disease receive screening mammograms annually in the U.S.
“Additionally, findings from this study will help us understand the implications of undergoing follow-up tests and treatment for these women and if they are a significantly greater burden for older women with dementia than those who are not cognitively impaired," Dr. Fowler said.
For more on the studies, visit the IU School of Medicine Newsroom.
Diversity Month events begin Jan. 8
On Monday, Jan. 8, IU School of Medicine kicks off a month of events in recognition of Diversity Month. This series of events explores different dimensions of diversity, including topics specific to diversity and inclusion in academic medicine. The Jan. 8 event, a Diversity Council Open Forum, will be held at noon in Daly 186. This month’s events also include:
Friday, Jan. 12: Diversity Affairs Social Hour
5 pm; Madame Walker Theater
Friday, Jan. 19: Department of Medicine Grand Rounds: Moving Beyond Cultural Competence Toward Equitable Patient-Centered Communication
Noon; Emerson Hall 304
Monday, Jan. 22: Stepping Stones of Women in Leadership (featuring Emily Walvoord, MD)
11:45 am; Fairbanks Hall 1112
Monday, Jan. 22: Unconscious Bias Presentation at IU School of Medicine-Fort Wayne
Dinner session: 6:30 pm (viewing available in Walther Hall 303)
Thursday, Jan. 25: Cultural Awareness Town Hall: Fourteen Years Later--On Barriers to Healthcare Faced by the Hispanic/Latino Community of Indianapolis
11:30 am; Walther Hall 203
Tuesday, Jan. 30: Asking Sexual Orientation and Gender Identity Questions in the History and Physical Exam
Noon; Van Nuys Medical Science Building, B26
Additional diversity programming is planned for 2018. To stay up to date, visit faculty.medicine.iu.edu.
Buy tickets now: the Second Year Show is next Friday
Don’t miss out on this year’s Second Year Show (2YS), which will be held at 7 pm, Friday, Jan. 12, at the Madame Walker Theatre in downtown Indianapolis. Led by IU School of Medicine MS2 students, this year’s show features “Ashleigh” and her difficulties adapting to the stressful environment of medical school.
Tickets for the show are $10 in advance and $15 at the door. Support this student-run initiative by buying a pre-sale ticket or making a donation. The IU School of Medicine Office of Diversity Affairs will sponsor a pre-show mixer with food and drinks.
Innovative brain-imaging study aimed at identifying at-risk kids
Faculty at Indiana University School of Medicine and Riley Hospital for Children at IU Health are looking to discover why some children and adolescents are more likely to engage in risky decision making than others through a unique brain-imaging study.
The study, led by Leslie Hulvershorn, MD, assistant professor of psychiatry, is the first of its kind to investigate the brain mechanisms associated with decision making which may predict the onset of risky behavior such as drug or alcohol use.
"We know that some children are more likely to make risky decisions and those children are more likely to go on to develop drug use disorders later in adolescence and adulthood,” said Dr. Hulvershorn. “Our team is interested in finding out more about brain mechanisms that underlie risky decision making before a child ever uses a drug of abuse.”
Children ages 11 and 12 are invited to participate as part of the study which is funded by the National Institutes of Drug Abuse. For more details on the study and contact information, visit the IU School of Medicine Newsroom.
Researchers find way to block malaria-causing parasite’s ability to shield itself from drug treatment
Indiana University School of Medicine researchers have identified a way to block the ability of parasites that cause malaria to shield themselves against drug treatments in infected mice—a finding that could lead to the development of new approaches to combat this deadly disease in humans.
Malaria is caused by a single-celled parasite called Plasmodium that is transmitted during a mosquito bite. Plasmodium parasites have evolved resistance to key antimalarial medications traditionally used to fight the disease, which is why there is an urgent need to identify new treatment strategies. Artemisinin is the active ingredient in the sweet wormwood bush that has been used for centuries as an antimalarial treatment in China. Today, artemisinin and its derivatives (known as ARTs) are among the most potent antimalarial medications used as the frontline treatment in more than 100 countries.
While ARTs can rapidly reduce the number of parasites in the blood, treatment with artemisinin fails for many patients because it appears that some parasites can enter a latent stage that allows them to ride out the presence of the drug. When patients finish their medication, these latent parasites reactivate and cause a relapse of the infection. This phenomenon is deemed a treatment failure, and it is emerging as a major clinical problem in battling malaria.
In a collaborative study published Dec. 13 in Cell Host & Microbe, a team of researchers led by Research Assistant Professor Min Zhang, PhD, of the IU School of Medicine Department of Pharmacology and Toxicology and the Department of Pediatrics, identified the molecular mechanism leading to ART treatment failures.
November research awards total more than $12 million
Investigator Sponsor Type Project Title Begin Date End Date Awarded Dollars Matthew R Allen University Of Colorado Colorado Springs New The Role of Bone Trait Covariation in Vertebral Fracture Resistance 9/1/17 8/31/18 24,652 Liana G Apostolova National Institute On Aging New Early Onset Alzheimer's Disease Consortium 9/15/17 8/31/18 7,654,317 Alan Breier Eskenazi Health New The Prevention and Recovery Center (PARC) for Early Psychosis Coordinated Specialty Care Program (Year 4A) 9/1/17 8/31/18 137,974 Alan Breier Eskenazi Health Renewal (not prev committed) Prevention and Recovery Center for Early Psychosis (PARC) and Coordinated Specialty Care (CSC) Network (YR1) 9/1/17 8/31/18 204,108 Cynthia Diane Brown Cincinnati Children's Hospital Medical Center New A Cystic Fibrosis Collaborative Chronic Care Network Care Model of the Future: Proposal for Piloting a Learning Health System 6/1/17 12/31/17 18,900 D Wade Clapp University Of Alabama Birmingham New NF Clinical Trials Consortium 8/15/17 8/14/18 30,000 Simon J Conway U.s. Department Of Veterans Affairs Renewal (not prev committed) VA H. Nakshatri, MD Research 10/1/17 9/30/18 13,850 Stephanie D Davis University Of North Carolina At Chapel Hill Renewal (not prev committed) Genetic Disorder of Mucocilary Clearance 8/1/17 7/31/18 58,940 Linda A DiMeglio Western Michigan University New Circadian Rhythmicity of Innate and Adaptive Immunity in T1D 6/1/17 5/31/18 62,873 Yansheng Du Purdue University New Lead Exposure on Beta-Amyloid Transport by Brain Barriers 8/15/17 7/31/18 200,811 Robert J Fallon Riley Children's Foundation Renewal (not prev committed) Stem Cell Transplant Chair - Wells Center 91-A6 7/1/17 6/30/18 72,902 Sherif S Farag University Of Michigan New University of Michigan Core Clinical Center for the BMT Research Network 7/26/17 6/30/18 28,500 Tatiana M Foroud Michael J Fox Foundation For Parkinsons Research Renewal (not prev committed) PPMI Biorepository 1/1/18 12/31/19 1,000,000 Tatiana M Foroud Michael J Fox Foundation For Parkinsons Research New Indiana University Genetics Biobank and Michael J Fox Foundation Fox Bionet Study 1/1/17 12/31/17 175,439 Flora Hammond University Of Washington New Improving Transition from Acute to Post-Acute Care following Traumatic Brain Injury 8/1/17 7/31/18 328,714 Flora Hammond Administration For Community Living New Indiana TBI Model System 9/30/17 9/29/18 435,000 Mark R. Kelley Riley Children's Foundation Renewal (not prev committed) Tom Wood Lexus Foundation Lexxll 12/1/17 11/30/18 24,600 Myda Khalid Nationwide Children's Hospital Renewal (not prev committed) Integrative Proteomics & Metabolomics for Pediatric Glomerular Disease Biomarkers 6/1/17 5/31/18 13,360 Jeffrey Allen Kline Medical College Of Wisconsin New Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN), Mid-America CTSA Consortium (MACC) 7/15/17 5/31/18 5,930 Heiko Konig Elsa U. Pardee Foundation New Novel role of hypoxia and hypoxic gradients in acute myeloid leukemia drug resistance 10/1/17 9/30/18 118,073 Kieren J Mather George Washington University Renewal (not prev committed) Glycemia Reduction Approaches in Diabetes: A comparative effectiveness study (GRADE) 9/6/17 7/31/18 534,968 Harikrishna Nakshatri Dr. Ralph And Marian Falk Medical Research Trust New The effect of extra physiologic oxygen shock/stress (EPHOSS) on cancer stem cell and drug sensitivity measurements. 11/30/17 11/29/18 300,000 Rick F Nelson Triological Society New Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids 10/1/17 9/30/18 80,000 Sara Kay Quinney Kaiser Foundation Research Institute New Resistance Training to Reduce Chemotoxicity in Colon Cancer 6/15/17 5/31/18 88,973 Jamie L Renbarger Riley Children's Foundation Renewal (not prev committed) Jeff Gordon Children?s Foundation Pediatric Oncology Physician Scientist Training Program (POPSTP) 7/1/17 6/30/18 250,000 Courtney Marie Rowan University Of Minnesota New Pediatric HSCT/Oncology Patient Critical Care Trials Group 1/1/17 12/31/17 3,500 Gregory M. Sokol Duke University New NICHD-2017-ABS02 Long-Term Outcomes Protocol of Premature Infants Enrolled in the NICHD-2013-ABS01 (SCAMP) Study 11/3/17 7/31/18 32,000 Michael S Sturek Boston University New In Vivo Photoacoustic Sensing of Lipid Laden Plaque 8/1/17 7/31/18 121,958 Michael S Sturek Northwestern University New Pilot Study of Bioresorbable Vascular Scaffolds 9/1/17 11/30/17 15,493 Sarah Elizabeth Wiehe Indiana State Department Of Health Renewal (not prev committed) 2017 Community Health Engagement Program Community-Based Research Pilot Projects 11/1/17 10/31/18 105,000 Xiao-Ming Xu U.s. Department Of Veterans Affairs New IPA Agreement/Liu 10/1/17 9/30/18 33,942 Xiao-Ming Xu U.s. Department Of Veterans Affairs New IPA Agreement/Wu 10/1/17 9/30/18 20,123
Faculty and Staff News
Cain named the Robert A. Garrett Professor of Pediatric Urologic Research
Mark P. Cain, MD, has been named the Robert A. Garrett Professor of Pediatric Urologic Research. This professorship was previously held by Richard C. Rink, MD, from 1997-2017. In addition to his new title, Dr. Cain will retain his current faculty title of professor of Urology.
Lab mentors, faculty and lecturers needed for CUPID summer program
Laboratory mentors, lecturers and clinical faculty are invited to participate in “Cancer in the Under-Privileged Indigent or Disadvantaged” (CUPID), a summer translational oncology program jointly administered by IU School of Medicine, the Johns Hopkins University School of Medicine and Ohio State University College of Medicine.
Now in its third year at IU School of Medicine, CUPID aims to cultivate an interest in cancer treatment and research among medical students who have not yet fully defined their career goals. Students interested in both research and health care disparities (rural and urban) and who have demonstrated a sustained commitment to community service are invited to apply. The 10-week, laboratory-based research experience will be held from May 28-Aug. 3, with IU School of Medicine hosting 4-6 students for the fellowship. During this period, students also will attend a didactic lunchtime lecture series featuring discussion about the molecular basis of cancer, general oncologic principles, challenges in clinical oncology and approaches to relieving cancer health disparities. They will also experience the clinical side of oncology through participation in half-day clinical rotations. Students will present research findings at a closing symposium.
Faculty are needed to host students in their labs (if located in Indianapolis), give lectures and provide shadow experiences in their clinics. Faculty mentors hosting a summer student in their laboratories will receive $1,000 to help cover lab-related expenses.
More details about CUPID and faculty volunteer opportunities are available. With questions or to volunteer, contact Joe Dynlacht, PhD, at firstname.lastname@example.org, or Richard Zellars, MD, at email@example.com.
Upcoming FEED event to explore connections between learner mistreatment and patient safety
Learner mistreatment and patient safety will be discussed at the next Faculty Enrichment and Education Development (FEED) event from 5:15-7 pm, Thursday, Jan. 18, in Fairbanks Hall, Room 1110. The session will identify important connections between learner mistreatment and patient safety. Registered participants will learn why learner mistreatment matters for all faculty and what they can do to mitigate this issue.
Providing an opportunity to learn in a collegial environment, FEED is a series of workshops on key topics in faculty development.
Successful proposal development is topic of Feb. 1 seminar
Basic processes for developing successful proposals to external funding agencies will be addressed in an event from 10-11:30 am, Thursday, Feb. 1, at University Library, Room 1126, on the IUPUI campus.
Topics include clarifying project objectives, matching project objectives to funding agencies, becoming familiar with funding agencies, basic budget construction, and communicating objectives and methods. Registration is not required.
Promotion and tenure information sessions begin Feb. 8
Plan now to attend a series of information sessions about the promotion and tenure process. The IU School of Medicine Office of Faculty Affairs and Professional Development partners each year with the school’s promotion and tenure committee to offer these special sessions. Dates and topics include:
Thursday, Feb. 8: General overview
Wednesday, Feb. 14: Documenting your work
Monday, Feb. 19: Preparing your CV
Wednesday, Feb. 21: Advancing to full professor
Monday, Feb. 26: eDossier nuts and bolts
Registration is available for each session.
Spring semester office hours for Dr. Allen
Have a question to ask or a comment to share? Bradley Allen, MD, PhD, senior associate dean, Medical Student Education, will be available to speak with students in Medical Science Building, MS 166, on the following days and times:
Wednesday, Jan. 17; noon-1 pm
Wednesday, Jan. 24; noon-1 pm
Wednesday, Jan. 31; noon-1 pm
Thursday, Feb. 8; noon-1 pm
Thursday, Feb. 15; noon-1 pm
Monday, Feb. 26; 11:30 am-1 pm
Thursday, March 8; noon-1 pm
Thursday, March 15; noon-1 pm
Thursday, March 29; noon-1 pm
Wednesday, April 11; noon-1 pm
Wednesday, April 18; noon-1 pm
Thursday, May 3; noon-1 pm
Thursday, May 10; noon-1 pm
Thursday, May 17; noon-1 pm
Letters of intent for diabetes research funding due Jan. 19
The IU Center for Diabetes and Metabolic Diseases is now accepting letters of intent (LOIs) for its pilot and feasibility program, which fosters the development of new diabetes-related investigators and provides seed support for innovative, high-risk projects. Investigators at Indiana University, IUPUI, Ball State, Notre Dame, the Indiana Biosciences Research Institute and Purdue are eligible for this funding opportunity.
The program is particularly directed to new investigators and established investigators new to diabetes-related research. It also will consider established diabetes investigators pursuing high-impact/high-risk projects or projects that are a significant departure from their usual work.
Application details are available. Letters of intent are due Friday, Jan. 19, and the full submission deadline is Monday, March 19.
March 5 is deadline to apply for CTSI-designated core facilities grants
The Indiana Clinical and Translational Sciences Institute (CTSI) seeks proposals from postdoctoral researchers to develop translational research through the use of technologies and expertise at the Indiana CTSI-designated core facilities available at all partner institutions. Translational research refers to research in the lab that eventually translates into patient treatment to improve human health care. Translation involves applying discoveries made during research (in the lab, through animal studies, etc.) to the development of clinical trials and studies in humans.
More information and application details are available. Deadline to submit applications is Monday, March 5.
Feb. 9 is deadline to apply for veteran-related research funding
The mission of the Indiana Institute for Medical Research (IIMR) is to promote and enhance research efforts that will ultimately result in improved quality of life for veterans and for the greater population. To support this mission, IIMR works to encourage investigators to develop their research careers by working with IIMR, the Veterans Administration and veterans to answer important questions. To this end, IIMR sponsors the annual Young Investigator Award Program, which provides a competitive experience for investigators to explore the possibilities of VA-related research.
Project budgets should be limited to funds necessary to carry out the research project and should not exceed $25,000. More information and application details are available. Letters of intent are due Friday, Jan. 12, and the full submission deadline is Friday, Feb. 9.
Sanborn recently honored with the Pride of Indiana recognition
Belinda Sanborn, IU School of Medicine Department of Anesthesia, was recently honored with Pride of Indiana recognition. Her nominator wrote, “A heartfelt thank you to Belinda Sanborn, who helped make the transition to MedHub in the Office of Undergraduate Medical Education a reality. Belinda's willingness to help and to go above and beyond with training sessions, one-on-one consultations and conference calls has been amazing. She has shared her experiences, both good and bad, while at the same time listening and incorporating others' ideas into making the product even better. I have never seen someone so willing to help others and so willing to help the IU School of Medicine succeed in its endeavor to bring the Office of Graduate Medical Education and Office of Undergraduate Medical Education together into a single platform. She is truly an inspiration."
Pride of Indiana is a regular Inside IU feature that allows IU faculty and staff to recognize colleagues for IU-related work that goes above and beyond job duties. Submit a Pride of Indiana nomination.