IU-led study of younger Alzheimer’s patients aims to pave the way toward new treatments

October 4, 2018

Indiana University School of Medicine scientists have received the university's largest single grant from the National Institutes of Health and will partner with a team of premier researchers around the country to lead a five-year national research study of a relatively rare form of Alzheimer's disease. Researchers hope the study will provide a foundation that may lead to new therapies for a disease that so far has resisted effective treatment.

The National Institute on Aging of the NIH has awarded IU a grant that is expected to total $44.7 million to fund the Longitudinal Early-onset Alzheimer's Disease Study. LEADS will follow participants diagnosed with early-onset Alzheimer's disease, which strikes people younger than 65 -- often in their 40s and 50s. The grant is in addition to a $7.6 million award last year that allowed planning and other start-up activity to begin for LEADS, bringing total federal support for the initiative to more than $52 million.

The study is led by IU School of Medicine neurologist and neuroscientist Liana Apostolova, MD, who is partnering with Maria C. Carrillo of the Alzheimer's Association; Brad Dickerson, MD, of Massachusetts General Hospital and Harvard Medical School; and Gil Rabinovici, MD, of University of California San Francisco.

For more on LEADS and the grant award, read the full news release.