Faculty and Staff News
Children’s Tumor Foundation honors Wade Clapp, MD, for contributions to research, clinical care
Wade Clapp, MD, endowed professor and chair of the Department of Pediatrics, recently received the Children’s Tumor Foundation’s prestigious Friedrich von Recklinghausen Award in recognition of Clapp’s significant contributions to neurofibromatosis (NF) research and clinical care. A neonatologist and physician-in-chief at Riley Hospital for Children at IU Health, Clapp is an expert in NF, a disease that causes tumors to grow on nerves and often begins in childhood. Over the years, Clapp has conducted internationally acclaimed research in NF and has funding from the National Institutes of Health.
"Dr. Clapp is one of the rare physician-scientists who is making significant breakthrough contributions to all forms of NF. From his contributions to the basic understanding of NF to the creation of key preclinical models, he is considered by many to be the global gold standard in this broad role,” said Annette Bakker, PhD, president of the Children's Tumor Foundation. “Dr. Clapp’s list of accomplishments in NF is very long, and he truly stands out in his commitment to unique collaborations."
For more the recognition and Clapp’s career, read the Faculty News blog post.
Van Nuys Medical Science Building renovations complete for fall 2020
IU School of Medicine is investing in enhancements to the student experience. The school recently completed updates to student spaces in the Van Nuys Medical Science Building.
Renovations to the fourth and fifth floors include comfortable lounge areas with plenty of outlets to charge mobile devices. The majority of medical student education courses at the Indianapolis campus are held in the Van Nuys Medical Science Building, which is adjacent to Riley Hospital for Children at IU Health.
This project is one of many IU School of Medicine facilities improvements designed to enhance the look, comfort, convenience and usability of campus spaces. Recent updates to the Daly Center include new furnishings, technology upgrades and added amenities in the student lounge and study areas, as well as fitness center improvements. Staff and faculty have begun moving into the upgraded space in anticipation of welcoming students back to campus.
Facilities improvements also are underway at several IU School of Medicine regional campuses, including the new Multi-Institutional Academic Health and Science Research Center in Evansville and the Regional Academic Health Center in Bloomington, scheduled for completion in late 2020. Ongoing facilities upgrades are part of IU School of Medicine’s commitment to supporting the health and well-being of its statewide campus community.
Weekly INScope issues to resume August 6
Beginning Thursday, August 6, INScope will resume its weekly publication schedule. As a reminder, the deadline for news item submissions is Wednesday at noon for each Thursday’s issue. Email submissions to firstname.lastname@example.org.
On the blog: Medical student recognized as Tillman Scholar
Guadalupe Jimenez remembers sitting in her guidance counselor’s office in Long Island, New York, discussing her plans for college, when the news broke that the twin towers had been hit on Sept. 11, 2001. Jimenez, a high school senior at the time, was considering applying to nursing school.
“We were taken out of our classrooms. The world stopped for us,” Jimenez said. “You have anger, you have all these emotions, and you want to turn it into something good.”
Deeply informed by her faith, Jimenez already knew she wanted a career that involved healing others. Determined to serve after the 9/11 attacks, she researched options for military service. Immediately after graduating high school the following spring in 2002, Jimenez enlisted in the U.S. Navy as a hospital corpsman. Hospital corpsmen play a critical role in providing emergency medical treatment to military personnel, including Marines and Sailors, who are injured in the field.
Nearly 19 years after that initial turning point, she has served three tours of duty as a hospital corpsman and is now pursuing a medical degree at IU School of Medicine. In recognition of her outstanding service and leadership, Jimenez was recently selected as a 2020 Tillman Scholar. She was one of 60 selected out of more than 1,700 applicants nationwide.
Pat Tillman, a professional football player with the Arizona Cardinals, left his sports career and enlisted in the U.S. Army in June 2002 in the aftermath of 9/11. An Army Ranger, Tillman served several tours in combat before he was killed in the mountains of Afghanistan in 2004. Following his death, family and friends established the Pat Tillman Foundation. As part of the foundation, the Tillman Scholars program supports the nation’s active duty service members, veterans and military spouses by investing in their education and professional development.
“This is something I am most proud of in my life,” Jimenez said. “I am morally obligated to ensure veterans are appropriately taken care of in the medical field.”
Read the full MD Student News blog post to learn more about Jimenez and her plans for the future.
June research awards total over $9 million
July research awards Investigator Sponsor Type Project Title Begin Date End Date Awarded Dollars Absalon, Sabrina Grace M. Showalter Trust New Functional investigation of key regulatory proteins in nuclear envelope assembly of malaria parasites 7/1/2020 6/30/2021 $50,000 Angus, Steve Grace M. Showalter Trust New Identifying therapeutic vulnerabilities in NF1-associated malignant peripheral nerve sheath tumors 7/1/2020 6/30/2021 $50,000 Basile, David Patrick Grace M. Showalter Trust New Showalter Scholar - David Basile 7/1/2020 6/30/2021 $25,000 Boente, Charline S Jaeb Center For Health Research Inc New A Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia (PEDIG-IXT5) 1/1/2020 12/31/2022 $5,250 Brault, Jeff National Institute Arthritis Musculoskeletal Skin New CELLULAR ENERGETICS AS A REGULATOR OF MUSCLE MASS AND MITOCHONDRIAL CONTENT DURING MUSCLE ATROPHY 7/1/2020 6/30/2021 $342,385 Clapp, D Wade National Institute Of Mental Health New Molecular Mechanisms of ADHD in Neurofibromatosis Type 1 7/1/2020 6/30/2021 $36,649 Desai, Ankit A Grace M. Showalter Trust New Showalter Scholar - Ankit Desai 7/1/2020 6/30/2021 $25,000 Dong, X Charlie National Institute Of Diabetes, Digestive & Kidney New Epigenetic regulation in liver fibrosis 7/1/2020 6/30/2021 $457,057 Evans-Molina, Carmella National Institute Of Diabetes, Digestive & Kidney Renewal (not prev committed) Indiana Diabetes Research Center 6/1/2020 5/31/2021 $1,541,053 Foroud, Tatiana M Parkinson's Disease Foundation Renewal (not prev committed) The Parkinson¿s Foundation Genetics Research Initiative 5/1/2020 5/31/2021 $503,611 Foroud, Tatiana M Michael J Fox Foundation For Parkinsons Research New Global Parkinson's Genetics Program (GP2) 1/1/2020 12/31/2020 $195,941 Gaston, Benjamin University Of North Carolina At Chapel Hill New Data, Modeling, and Coordination Center for PrecISE Network (Genomics Core) 7/1/2019 6/30/2020 $131,910 Geraci, Mark W Cardiovascular Medical Research Education Fund New Pulmonary Hypertension Breakthrough Initiative (PHBI) 7/1/2019 6/30/2021 $288,000 Jerde, Travis J National Institute Of Diabetes, Digestive & Kidney New Interleukin-1 and Steroid Signaling Drive Toxoplasma-induced Prostatic Hyperplasia 5/15/2020 2/28/2021 $531,627 Johnson, Philip L National Institute Of Mental Health New Mechanisms of Serotonin Modulation of Panic 3/12/2020 12/31/2020 $595,174 Kennedy, Lindsey American Association For The Study Of Liver Diseases New Sex-Dependent Estrogen Signaling Promotes Mast Cell Activation and Histamine Signaling in Primary Biliary Cholangitis 7/1/2020 6/30/2021 $20,000 Kline, Jeffrey Allen Medical College Of Wisconsin New MACC/EPICC-Net as a Hub for the HEAL Initiative EPICC-Net 9/18/2019 8/31/2020 $6,714 Konig, Heiko Leukemia Research Foundation New A novel approach to target drug resistant acute myeloid leukemia cells 9/1/2020 8/31/2021 $100,000 Kubal, Chandrashekhar Avinash Johns Hopkins University New HOPE in Action: A Clinical Trial of HIV-to-HIV Liver Transplantation 8/1/2019 7/31/2020 $9,500 Lai, Charly University Of Pittsburgh Renewal (not prev committed) A Phase II Trial for Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction 3/1/2020 2/28/2021 $31,500 Landreth, Gary Eugene Brightfocus Foundation New Role of HK2 in TREM2-mediated microglial response in AD 1/1/2021 12/31/2022 $200,000 Langer, Mark P. Research Foundation State University New York New A Dual Quaternion Based Method for Estimating PTV Margins in Intensity-Modulated Radiotherapy 5/7/2020 4/30/2021 $39,375 Liu, Yan Us Army Medical Research Acquisition Activity New Targeting Leukemia-Initiating Cells to Improve Leukemia Treatment 8/1/2019 7/31/2021 $607,046 Lu, Tao Grace M. Showalter Trust New Showalter Scholar - Tao Lu 7/1/2020 6/30/2021 $25,000 Lu, Xiongbin University Of Maryland New Nanotechnology for targeted therapy and fundamental understanding of therapeutic resistance in triple negative breast cancer 4/1/2020 3/31/2021 $216,041 Markusic, David Michael Grace M. Showalter Trust New Developing Treg immunotherapies for food allergy. 7/1/2020 6/30/2021 $75,000 Meng, Fanyin Psc Partners Seeking A Cure New The beneficial effects of endothelial progenitor cells in primary sclerosing cholangitis 5/1/2020 4/30/2022 $60,000 Meyer, Jason Brightfocus Foundation New Astrocyte effects on RGCs in a stem cell model of glaucoma 9/1/2020 8/31/2022 $180,000 Monje, Paula Indiana State Department Of Health New Preclinical Development of Human Peripheral Nerve-Derived Therapeutic Products 7/1/2020 6/30/2022 $100,000 Moorthi, Ranjani N Grace M. Showalter Trust New Serum Metabolites and Sarcopenia in Patients on Hemodialysis 7/1/2020 6/30/2021 $50,000 Natoli, Roman M Indiana University Health New Early Serial Sampling of Peripheral Blood for the Purposes of Predicting Fracture Nonunion: A Pilot Study 7/1/2020 6/30/2023 $150,000 Perna, Fabiana Leukemia Research Foundation New Interrogation of the Leukemia cell Surfaceome for Immune-targeting 7/1/2020 6/30/2021 $100,000 Pierchala, Brian National Institute Neurological Disorders & Stroke New A p75/Ret receptor complex as an integrator of survival and death 6/15/2019 4/30/2020 $337,764 Sen, Chandan K Us Army Medical Research Acquisition Activity New Activating Fetal Regeneration in Adult Tissue 4/15/2020 4/14/2022 $315,000 Stefanidis, Dimitrios Indiana University Health New Developing a Competency-Based Education Curriculum for Surgery Residents 7/1/2020 6/30/2022 $98,457 Sullivan, William J. Grace M. Showalter Trust Renewal (not prev committed) Disrupting RNA modification as a novel treatment for parasitic infection 7/1/2020 6/30/2021 $60,000 Unroe, Kathleen T National Institute On Aging New UPLIFT-AD (Utilizing Palliative Leaders in Facilities to Transform care for Alzheimer's Disease) Intervention 6/15/2020 3/31/2021 $808,236 Wek, Ronald C. Grace M. Showalter Trust Renewal (not prev committed) Translation and Stress Regulatory Pathways in Health and Disease 7/1/2020 6/30/2021 $60,000 Yang, Frank National Institute Allergy & Infectious Diseases New Targeting Cyclic Dinucleotide Signaling Pathways to Interrupt the Nature Cycle of Borrelia burgdorferi 6/9/2020 5/31/2021 $659,925 Zimet, Gregory D Society Of Family Planning New Digital storytelling as a tool to reduce abortion stigma among Black people who have had abortions in the US 11/1/2019 10/30/2020 $7,500 Zyromski, Nicholas Joseph Foundation For Surgical Fellowships New HPB surgical fellowship grant 8/1/2021 7/31/2022 $20,000
Toxoplasma study reveals how a dangerous parasite controls its host cell to spread around the body
IU School of Medicine researchers have discovered new information about how a dangerous parasite takes control of a patient’s cells as it spreads throughout their body, an important finding that could help in the development of new drugs to treat this infection.
“The parasite essentially hijacks these cells, using them as vehicles to get to various organ systems, including the brain,” said Leonardo Augusto, PhD, a postdoctoral fellow in the Department of Pharmacology and Toxicology and lead author on the National Institutes of Health-funded study, which was recently published in mBio. “It’s like the parasite is taking the wheel of its host cell and using it to spread around the body.”
Toxoplasma gondii infects up to one-third of the world’s population. People typically become infected with it through exposure to cat feces, which is where it goes through its reproductive phases, or consumption of contaminated food and water. The parasite causes life-threatening issues in some patients because of its ability to disseminate to the brain. In the brain and other tissues, the parasite persists as a latent cyst, waiting to reactivate if immunity should wane, such as what happens in HIV/AIDS patients.
“One of the key problems in battling an infection like Toxoplasma is controlling its spread to other parts of the body,” Augusto said. “Upon ingestion of the parasite, it makes its way into immune cells and causes them to move—a behavior called hypermigratory activity. How these parasites cause their infected cells to start migrating is largely unknown.”
Learn more about the research discovery in the Newsroom.
International collaboration aims to help lower infant deaths
An international collaboration aimed at adapting existing technology to reduce infant mortality in Indiana received a two-year grant from Indiana Clinical and Translational Sciences Institute (CTSI) and the Indiana University (IU) Center for Global Health.
Researchers at IU School of Medicine, Purdue University Weldon School of Biomedical Engineering and Moi University School of Medicine in Kenya will receive up to $50,000 through the Global Health Reciprocal Innovation Demonstration grant program.
The researchers will investigate if NeoWarm and KickSTART technology can be combined to generate new innovations to reduce infant mortality and help opioid-exposed babies. NeoWarm is a wearable biomedical device for premature and low birthweight babies that includes a self-warming pouch and carrier, as well as a system to monitor vital signs and alert caregivers if the newborn’s body temperature fluctuates from a normal range. KickSTART is smartwatch technology originally developed to continuously monitor vital signs and detect overdose among adult opioid users.
“A disproportionate amount of infant mortality, globally, occurs during the newborn period,” said Sherri Bucher, PhD, associate research professor of pediatrics at IU School of Medicine and lead principal investigator for the project. “Innovations that can lessen the complications from underlying causes of newborn mortality, such as premature birth and prenatal drug exposure, also have high potential impact to reduce global rates of infant mortality. Through the collaborative reciprocal innovation process, our work with international partners can identify solutions that work in many different settings.”
For more, visit Indiana CTSI.
Faculty and Staff News
Strachan named Evans Fellow
Christian C. Strachan, MD, assistant professor of clinical emergency medicine, was selected by IU School of Medicine, IU Health and IU Health Physicians as the 2020-21 Evans Fellow in Health Care Leadership.
Named in honor of Daniel F. Evans, Jr., JD, president emeritus of IU Health, the Evans Fellowship program is designed to provide a mid/senior physician faculty member with executive education, personal leadership assessments and coaching, and structured networking and mentoring opportunities. The two-year leadership fellowship also includes structured coursework leading to a Masters in Business Administration from the IU Kelley Business of Medicine program.
More information is available in this Faculty News blog post.
Box at IU retirement: Here’s how to request new institutional and secure storage
In preparation for the retirement of Box at IU, IU will no longer be adding new folders/collaborators to Box Health starting Wednesday, August 5. As announced in June, files in Box Health will be migrated to Microsoft at IU Secure Storage.
- Request new Microsoft at IU Secure Storage, Google at IU Secure Storage or group storage accounts by using this form. This form can also be used to request regular storage.
- Note: Current non-individual and Box Entrusted account owners will have a separate process to request the preferred service. This ensures each new environment has the needed security attributes, and appropriate people/accounts have the necessary access.
- If interested, sign up to attend regularly schedule webinars about preparing for the move and understanding the Microsoft and Google cloud storage environments. Recordings of these sessions are also available.
Questions about the transition? Contact UITS or talk directly with the school’s Health Technology Services staff.
Ask Me Anything office hours scheduled for August 4 and 13
Do you have questions, thoughts or feedback about research, teaching, diversity initiatives and more? Ask a dean during Ask Me Anything office hours—an open, dedicated time to ask questions and provide feedback to school leaders in Faculty Affairs, Faculty Development and Diversity. Any member of the IU School of Medicine community may participate. These special office hours will be held monthly on the first Tuesday from 1-2 pm and the second Thursday from 10-11 am. Learn more.
Register for the upcoming Indiana CTSI virtual annual meeting
Registration is now open for the 2020 Indiana Clinical and Translational Sciences Institute (CTSI) Annual Meeting, which will be held virtually from 9 am-2 pm, Friday, September 11.
The theme for this year's event is "Improving Health from Individuals to Communities." Attendees can expect:
- Keynote address from Brian Druker, MD, director, Oregon Health & Science University Knight Cancer Center Institute
- Presentations about Indiana CTSI-led innovations from Indiana University, Purdue University and the University of Notre Dame
- Concurrent breakout rooms for poster sessions
- Remarks from the new Indiana CTSI co-directors, Sharon Moe, MD, and Sarah Wiehe, MD, MPH,
Visit Indiana CTSI for the agenda, registration and poster submission details.
Apply by August 17 for Translational Cancer Biology Training Program
The Translational Cancer Biology Training Program (TCBTP) is designed to enhance the training received in any individual laboratory or department. Trainees are exposed to a broad range of cancer-related research encompassing both basic and clinical aspects of the disease. TCBTP predoctoral students fulfill the requirements of their individual basic science departments and complete the cancer biology minor. Pre-doctoral CBTP trainees attend both a basic science and a clinical seminar series, co-sponsored by the IU Simon Cancer Center and participate in the IU Simon Cancer Center's annual Cancer Research Day.
TCBTP stipends are available on a competitive basis for trainees conducting their research in the laboratory of a TCBTP preceptor. Candidates must be U.S. citizens or permanent residents. More information is available. Email Harikrishna Nakshatri, PhD, at email@example.com with questions. Application deadline is Monday, August 17.
Eli Lilly-Stark neurosciences research fellowship applications due September 21
The Stark Neurosciences Research Institute and the Indiana Clinical and Translational Sciences Institute (CTSI) seek applicants for predoctoral and postdoctoral research fellowships in translational neurodegenerative disease research. Applicants whose research focuses on age-related neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, chronic traumatic encephalopathy and others are encouraged to apply.
September deadline to apply for Alzheimer’s disease research fellowship
Through a generous donation from James R. and Nancy E. Carpenter, as well as a matching contribution from the Stark Neurosciences Research Institute, the Indiana Alzheimer Disease Center established the Sarah Roush Memorial Fellowship in Alzheimer’s Disease Research. The award is an annual postdoctoral fellowship supplement that will provide $22,500 per annum to enhance current research in the field of Alzheimer’s disease or other neurodegenerative dementing illnesses. The application can be focused on clinical, neuropsychological, basic or other specific type of research on Alzheimer’s disease and related disorders. More information is available. Deadline to apply is Monday, September 21.
Pilot funding available for alcohol use disorders research
The Indiana Alcohol Research Center (IARC) seeks proposals for a pilot project from investigators who want to develop research on alcohol use disorders. Applications related to basic mechanisms and genetic underpinnings of alcohol preference or compulsive drinking and tolerance are welcome. The purpose of an IARC pilot grant is to allow an investigator to obtain preliminary data leading to extramural funding. Previous experience in research on alcoholism is not required. Letters of intent are due Saturday, August 1. Full application deadline is Thursday, October 15. Get the details.
IU Health to host “Caring for Jewish Patients and Families”
Join IU Health for a statewide conversation on caring for Jewish patients and families. The event will be held virtually from 10 am-noon, Tuesday, August 4. The conversation will include a panel of local Jewish leaders and cover key clinical topics. Continuing education credits will be available.
Participate via Zoom or by phone: +1 301 715 8592 (US Toll) or +1 312 626 6799 (US Toll). The event is the second in the statewide series of Conversations on Spirituality, Faith and Health sponsored by The Evans Center for Spiritual and Religious Values in Healthcare and IU Health Chaplaincy.
Riley Children’s Health names new CNO
Megan Isley, DNP, MBA, RN, CPNP, NEA-BC, NPD-BC, has been named the new chief nursing officer for Riley Children’s Health. Isley comes to Riley from Cincinnati Children’s Hospital Medical Center, where she was assistant vice president of patient services and, before that, clinical director of the ambulatory heart institute. Previously, she was a clinical manager at Nationwide Children’s Hospital in Columbus, Ohio, and a pediatric nurse practitioner and clinical educator at Duke University Health System in Durham, North Carolina.
Isley holds doctor of nursing practice and master’s degrees in nursing from Duke University, and a master’s in business administration and bachelor’s degrees in nursing from West Liberty University in West Virginia.
Selected after a comprehensive national search, Isley will join the Riley leadership team on Monday, August 31.
IU Health logo face masks for sale
IU Health is now offering cloth face masks emblazoned with the healthcare system’s logo. These non-medical masks are not certified and are not for use in settings where patient care is provided. They do offer some protection against the spread of COVID-19, and may be worn in IU Health administrative spaces, other non-patient care settings and out in public.
The logo masks are available in white and black colors, and are available for $3.50 each (plus shipping). The masks are reusable and washable and are intended for adult use only. Purchase masks online.
Neal elected Fellow of the Royal College of Physicians – LondonJ. Matthew Neal, MD, assistant dean for faculty development, has been elected a Fellow of the Royal College of Physicians – London, the oldest medical college in England. Candidates are chosen based on their service in the field or contributions to medical education or research and other criteria. Neal is one of the few physicians elected who did not train in the United Kingdom.
Rhodes named Collins Scholar for neurofibromatosis research
Steven Rhodes, MD, a fellow in the hematology-oncology program, has been selected as a Francis S. Collins Scholar, receiving substantial support from the Neurofibromatosis Therapeutic Acceleration Program at Johns Hopkins University. Rhodes is conducting post-doctoral research for the treatment of neurofibromatosis.
The Collins Scholars program is named in honor of the physician-scientist who led the team that discovered the NF1 gene in 1990. Collins remains at the forefront of advancing translational science as director of the National Institutes of Health.
For more on Rhodes and the scholars program, read the Faculty News blog post.