Faculty and Staff News
Save the date: Spring All School Meeting is May 4
IU School of Medicine Dean Jay Hess, MD, PhD, MHSA, and the Faculty Steering Committee invite faculty, staff and learners to attend the spring All School Meeting from 5-6:30 pm, Tuesday, May 4. The meeting will be held virtually, and registration is now available.
The All School Meeting, held twice a year in the spring and fall, offers a chance for the school community to hear updates from Hess and the executive associate deans. Visit the Faculty Steering Committee webpage for more details.
Final Diversity Town Hall is next Thursday; register today
The final session in the current Diversity Town Hall series will be held from 4-5 pm, Thursday, February 25. Dean Jay L. Hess, MD, PhD, MHSA, hosts the virtual discussions, which include updates from the diversity, equity and inclusion task forces. The task forces recently shared the first quarterly update of the initiative. Register for the final session in this series.
If you have questions or would like to provide feedback, suggestions or ideas before the meeting, you can share them in advance. There will be an opportunity to participate through breakout sessions during the town hall session.
Check out the top 10 recipients of NIH funding for federal fiscal year 2020
IU School of Medicine set another record for NIH-funded research last year. The school’s faculty attracted federal support for research about Alzheimer’s disease, genomic-guided therapies, cancer research and more. Check out the projects that were awarded the largest grants in this Research Updates blog post.
On the blog: Spreading positivity and hope on the front lines of COVID-19
It’s been about a year since COVID-19 patients first flooded intensive care units (ICU) around Indiana. IU School of Medicine Bicentennial Professor W. Graham Carlos, MD, who also serves as the chief of medicine at Eskenazi Health, spends most of his time in the ICU and has watched several surges during the last few months.
Last spring, Eskenazi Health had to expand ICU capacity by 400%, quadrupling their ICU beds and leveraging the staff they had to help take care of the influx of patients.
“We worked together as a team to address the problems of the day and take care of patient needs,” said Carlos. “We meet many people on the worst day or worst week of their life. I really try to instill humanism in medicine and compassionate care, all the while showing my residents and students how to do the same thing.”
Read more of Carlos’ insights from the front lines of the pandemic in this Research Updates blog post.
January research awards total more than $5.9 million
January research awards Investigator Sponsor Type Project Title Begin Date End Date Awarded Dollars Malaz A Boustani National Institute On Aging New Digital Detection of Dementia Studies (D cubed Studies) 9/30/2020 5/31/2021 $1,094,329 Timothy W Corson Retina Research Foundation New Localization and lipid modulation of soluble epoxide hydrolase in choroidal neovascularization 1/1/2021 12/31/2021 $40,000 Carmella Evans-Molina Riley Children's Foundation Renewal (not prev committed) Luke Bracken Wiese Fund for Juvenile Diabetes at Riley Hospital for Children 1/1/2021 12/31/2021 $100,000 Thomas H Everett Purdue University New Noninvasive, multimodal system to detect autonomic dysreflexia in individuals with tetraplegia 9/30/2020 9/29/2023 $65,493 Ryan Everett Fitzgerald Pediatric Spine Foundation New Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS) 1/5/2021 1/4/2026 $20,350 Tatiana M Foroud Lumind Foundation Renewal (not prev committed) Down Syndrome Biorepository 1/11/2021 12/31/2023 $167,988 Tatiana M Foroud Michael J Fox Foundation For Parkinsons Research New Global Parkinson's Genetics Program (GP2) - 2021 Working Group Lead 1/1/2021 12/31/2021 $25,000 Tatiana M Foroud University Of Pennsylvania New Asian Cohort for Alzheimer's Disease (ACAD) 9/30/2020 5/31/2021 $93,268 Tatiana M Foroud Broad Institute Renewal (not prev committed) Schizophrenia Spectrum Biomarkers Consortium (SSBC) Pilot 1/1/2021 6/30/2021 $65,081 Woody Hopf Emil And Rita Weissfeld Family Foundation Inc New Biomedical research involving animals 12/15/2020 12/14/2021 $5,000 Alan P Ladd Riley Children's Foundation New Riley Children's Endowment Grant #21-A36 Chairman of Surgery Grant 7/1/2020 6/30/2021 $22,000 Xiongbin Lu Medical University Of South Carolina New Dual targeting of tumoral microenvironment and tumoral cells by blocking the IL- 33/ST2 pathway (ST2 as checkpoint target for childhood solid tumors) 8/6/2020 7/31/2021 $128,453 Paul Musey Patient-centered Outcomes Research Institute New Addressing Anxiety among Low-Risk Chest Pain Patients in the Emergency Department 1/1/2021 12/31/2024 $2,862,113 R. Mark Payne Additional Ventures New Development of a metabolic biomarker panel to identify SV patients at risk for heart failure. 1/15/2021 1/15/2024 $652,540 Jeffrey S Raskin Hospital For Sick Children New Predicting Seizure Responsiveness to Neuromodulation Using Connectomic Profiling 4/1/2019 3/31/2023 $3,700 Clement L Ren Cystic Fibrosis Foundation Renewal (not prev committed) First and Second Year Clinical Fellowship 7/1/2020 6/30/2021 $66,750 Jason Michael Spaeth National Institute Of Diabetes, Digestive & Kidney New The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivo 1/1/2021 12/31/2021 $118,875 Michael S Sturek Boston University New Sensing Vulnerable Plaque in vivo by An All-optical Intravascular Ultrasound and Photoacoustic Catheter 9/1/2020 8/31/2021 $42,461 Tuan M Tran National Institute Allergy & Infectious Diseases New Investigating gene regulatory networks in immune cells of children who differ in susceptibility to malaria infection using single-cell approaches 1/1/2021 12/31/2021 $317,000 Weidong Xiao U.s. Department Of Agriculture New Effects of Chlorine on Gut Microbiota in the Mouse Models 9/1/2020 8/31/2021 $29,998
IU research team identifies disease-related gene changes in kidney tissue
Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease. They will contribute their findings to the Kidney Precision Medicine Project’s (KPMP) “cell atlas,” a set of maps used to classify and locate different cell types and structures within the kidney.
They shared their groundbreaking findings in a recent study published in Science Advances.
In the study, researchers investigated the kidney tissue of healthy people and people with diabetes using a technique called “regional transcriptomics.” This technique involves a rapid stain of kidney tissue and then using a laser to cut out microscopic regions of interest.
They found that important genes change when a scar forms on the interstitium, said Daria Barwinska, PhD, the lead author of the study and an assistant scientist in the IU School of Medicine Department of Medicine.
“The interstitium is the ‘glue’ that holds the kidney together. It is one of the least characterized parts of the kidney, but scars in the interstitium caused by diseases such as diabetes can contribute to kidney disease,” said Barwinska.
For more on the study, visit the Newsroom.
Researchers build on Indiana CTSI funding to develop non-pharmacological approach for Alzheimer’s disease
Researchers at IU School of Medicine are utilizing a promising new approach to tackle Alzheimer’s disease (AD) that doesn’t involve medication. Instead, Debomoy Lahiri, PhD, Felipe Perez, MD, and their research team are focused on Repeated Electromagnetic Field Stimulation (REMFS) and recently published an article in Nature Scientific Reports to share their progress.
Researchers believe the presence of misfolded proteins or protein fragments in the brain contribute to AD. Those are known as amyloid plaques—which are found between the brain’s nerve cells—and tau tangles—which are found inside the brain’s nerve cells.
Lahiri and Perez found that using REMFS in primary human brain (PHB) cultures can decrease toxic amyloid plaque levels. They looked at the effects of this noninvasive strategy on various levels, using different frequencies and powers. After exposing the PHB cultures to REMFS for one or two hours a day, they found significantly lower levels of amyloid plaque. This happened in multiple scenarios, including repeating the exposure for 4, 8 or 14 days. The study team also found this did not damage the neuron membranes.
For more on the study and its connection to a previously awarded Indiana CTSI grant, visit Indiana CTSI.
Faculty and Staff News
Winter weather continues: Review the adverse weather policy
This week’s weather is a harsh reminder that spring is still a few weeks away. With inclement winter weather lingering, take a moment to review the adverse weather policy for staff and employees working on IU campuses.
While the university does not normally close during adverse weather, there will be times when certain employees cannot travel to work, may arrive late or may need to leave early. Employees are expected to use their best judgment when traveling to or from work and should not endanger themselves or ignore the notifications of local officials.
LPR technology coming to IUPUI parking: What you need to know (and do)
IUPUI Parking and Transportation Services is deploying license plate recognition technology (LPR) to increase parking efficiency on campus, reduce manual processes, create conveniences for customers, and greatly reduce the amount of paper and plastic waste created by permit production.
Additionally, LPR cameras will count open parking spaces in surface lots and garages. This information can integrate with an app or other technologies for permit-holders to find open parking spaces on campus in real time. This system is expected to be deployed in five phases over the next three to five years, with the goal of full implementation by 2026.
To assist with the testing and implementation of LPR, faculty, staff and students should ensure their vehicle information is up to date through the online parking portal. Learn more about the upcoming parking changes.
Need current info on COVID-19 vaccines? These resources can help
The State of Indiana is now allowing people age 65 and older to sign up for vaccination. Individuals currently able to receive the COVID-19 vaccine include:
- Individuals age 65 or older.
- Those who work or volunteer in health care and have (physical or close) contact or face-to-face interactions with patients.
- Those who have exposure to COVID-19 infectious material.
Register for IU School of Medicine Education Day; event is April 22
The second annual IU School of Medicine Education Day will be held from noon-5 pm on Thursday, April 22. Focusing on “Adaptability in Medical Education,” Education Day offers an opportunity for students, residents, fellows, faculty and staff from all departments and campuses to showcase their medical education research. Oral presentations, small group discussions, workshops and poster sessions will be featured. Registration is now open for the virtual event
More information, including the agenda, is available in this Research in Medical Education blog post.
Sign up for next month’s virtual LGBTQ Health Care Conference
Don’t forget to register for the upcoming LGBTQ Health Care Conference, which will be held virtually on Thursday, March 25, and Friday, March 26. The two-day event is open to anyone seeking to understand the unique health considerations and barriers to health care in the LGBTQ population.
Conference attendees will learn how to provide respectful, patient-centered, culturally competent health care to LGBTQ individuals with an emphasis on developing skills to:
- Establish rapport
- Recognize barriers to medical care
- Offer LGBTQ patients competent primary care and/or referrals to such care
- Identify the unique health risks in the LGBTQ population
See the topics for this spring’s Culture and Conversation events
Culture and Conversation is a monthly lunch discussion series that addresses culturally relevant topics, health equity and current events. The virtual events are open to faculty, staff, students and leadership. Registration is now available for these spring Culture and Conversation events:
Tuesday, March 9
Register and learn more.
Health + Data. Making data-informed decisions
Tuesday, April 13
Register and learn more.
Policing and Health Care
Tuesday, May 18
Register and learn more.
Teen vaping ECHO series begins March 5
The teen vaping ECHO (Extension for Community Healthcare Outcomes), sponsored by the Indiana Department of Health, will be offered weekly on Friday at noon beginning Friday, March 5, and continuing through Friday, May 21. The program is free for Indiana health care professionals who wish to learn more about the management of vaping/e-cigarette use and related conditions in adolescents. Register for the program.
Indiana CTSI Visiting Scholars Program featured in prominent journal
A paper written by members of the Indiana CTSI has been published in the Journal of Clinical and Translational Science.
The article, “Visiting Scholars Program to Enhance Career Development among Early Career KL2 Investigators in Clinical and Translational Science: Implications from a Quality Improvement Assessment,” highlights the benefits and successes of the CTSI Career Development Award (KL2) program. The article touches on what the program is, its history and the application and selection processes.
The KL2 Visiting Scholars Program was created to provide early career scholars with the opportunity to advance their program of research, collaborate with several institutions and expand professional networks. According to the article, 12 scholars have already completed the program and six are scheduled to finish in 2021.